Shoya Tomizawa
The 19-year-old rider was exiting turn 10 of the Misano circuit when he slid off in a 'lowside' crash at full speed.
The bikes of Alex De Angelis and Scott Redding, who were following in close pursuit, crashed violently into Tomizawa as he slid along the tarmac.
Tomizawa was immediately taken to hospital following the incident, but later died from his injuries and was pronounced dead at 2.20pm local time.
Shoya Tomizawa crash Picture
Shoya Tomizawa Video Dies
A statement on the MotoGP website confirmed: 'On Sunday 5th September during the Moto2 race at the Misano World Circuit, rider Shoya Tomizawa aged 19 suffered a serious crash and subsequent cranial, thoracic and abdominal trauma.'
De Angelis and Redding are believed to have sustained minor injuries in the incident. Riders in the premier MotoGP class were informed of Tomizawa's death following the race.